Regional homogeneity patterns reveal the genetic and neurobiological basis of State-Trait Anxiety.

ABSTRACT:

Objective

State anxiety and trait anxiety are differentially mapped in brain function. However, the genetic and neurobiological basis of anxiety-related functional changes remain largely unknown.

Methods

Participants aged 18-30 from the community underwent resting-state fMRI and were assessed with the State-Trait Anxiety Inventory. Using a general linear regression model, we analyzed the effects of state and trait anxiety, as well as their sum and difference (delta), on regional homogeneity (ReHo) in cortical areas. ReHo patterns denote the spatial distribution of ReHo associated with anxiety scores. We further explored the spatial correlations between ReHo patterns and neuromaps, including gene expression, neurotransmitter receptor density, myelination, and functional conne

SUBMITTER: Li Y 

PROVIDER: S-EPMC11577826 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature