Post-sepsis chronic muscle weakness can be prevented by pharmacological protection of mitochondria.

ABSTRACT:

Background

Sepsis, mainly caused by bacterial infections, is the leading cause of in-patient hospitalizations. After discharge, most sepsis survivors suffer from long-term medical complications, particularly chronic skeletal muscle weakness. To investigate this medical condition in detail, we previously developed a murine severe sepsis-survival model that exhibits long-term post-sepsis skeletal muscle weakness. While mitochondrial abnormalities were present in the skeletal muscle of the sepsis surviving mice, the relationship between abnormal mitochondria and muscle weakness remained unclear. Herein, we aimed to investigate whether mitochondrial abnormalities have a causal role in chronic post-sepsis muscle weakness and could thereby serve as a therapeutic target.

Methods

Ex

SUBMITTER: Kingren MS 

PROVIDER: S-EPMC11577827 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature