The mediating role of inflammation in the association between cotinine levels and remnant cholesterol: a cross-sectional study.

ABSTRACT:

Background

Remnant Cholesterol (RC) has emerged as a significant risk factor for cardiovascular disease. However, the factors influencing RC levels remain incompletely understood. This research investigates smoking-a major modifiable risk factor-to elucidate its impact on RC levels and examine the mediating role of inflammation in this relationship.

Methods

Using NHANES data from 1999 to 2018, this study analyzed the association between serum cotinine levels (a biomarker of smoking intensity) and RC in 8,829 participants aged 20 years and older. Through complex sampling design and adjustment for multiple covariables, we examined both linear and nonlinear relationships using linear regression models, restricted cubic splines (RCS), and subgroup analyses. Additionally, mediati

SUBMITTER: Lai T 

PROVIDER: S-EPMC11577861 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature