Associations of epigenetic age acceleration at birth and age 12 years with adolescent cardiometabolic risk: the HOME study.

ABSTRACT:

Background

Cardiometabolic risk factors among youth are rising. Epigenetic age acceleration, a biomarker for aging and disease-risk, has been associated with adiposity in children, but its association with other cardiometabolic risk markers remains understudied. We employed data from the Health Outcomes and Measures of the Environment (HOME) study, a prospective pregnancy and birth cohort in the greater Cincinnati metropolitan area, to examine whether accelerated epigenetic age at birth as well as accelerated epigenetic age and faster pace of biological aging at age 12 years were associated with higher cardiometabolic risk in adolescents.

Results

After adjusting for potential confounders, including estimated cell type proportions, epigenetic gestational age acceleration at b

SUBMITTER: Arzu JL 

PROVIDER: S-EPMC11577890 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature