Genetically predicted circulating linoleic acid levels and risk of osteoarthritis: a two-sample mendelian randomization study.

ABSTRACT:

Objectives

This study aimed to provide insight into the effect of genetically predicted linoleic acid (LA) levels on osteoarthritis (OA).

Methods

The LA dataset was obtained from the UK Biobank (UKBB) consortium and contained 114,999 samples. The OA discovery dataset was derived from MRC-IEU consortium and included 38,472 cases and 424,461 controls. The OA validation set was derived from a summary-level genome-wide association study (GWAS) and included 39,427 cases and 378,169 controls. Genetic variants strongly associated with LA (p < 5 × 10^- 8) were extracted as instrumental variables (IVs). The inverse variance weighted (IVW) approach was adopted as the primary analysis method in this study. In addition, multiple sensitivity analysis methods were used to assess

SUBMITTER: Yang W 

PROVIDER: S-EPMC11577923 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature