Antibacterial activity of the structurally novel C-2 amine-substituted analogues based on quinoxaline.

ABSTRACT: In the current study, we have designed and prepared a series of quinoxaline-based compounds, which were derived from o-phenylenediamine. Among them, compounds 5m-5p displayed good to moderate antibacterial activity with MICs of 4-16 μg mL^-1 against S. aureus, 8-32 μg mL^-1 against B. subtilis, 8-32 μg mL^-1 against MRSA and 4-32 μg mL^-1 against E. coli, respectively. Compound 5p, identified as a potent broad-spectrum antibacterial agent, demonstrated the strongest inhibitory effects against a range of bacterial strains and low cytotoxicity, thereby warranting further investigation. Compound 5p not only demonstrated the ability to disperse established bacterial biofilms but also induced a slower development of bacterial r

SUBMITTER: Liu Y 

PROVIDER: S-EPMC11577936 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature