Graph databases in systems biology: a systematic review.

ABSTRACT: Graph databases are becoming increasingly popular across scientific disciplines, being highly suitable for storing and connecting complex heterogeneous data. In systems biology, they are used as a backend solution for biological data repositories, ontologies, networks, pathways, and knowledge graph databases. In this review, we analyse all publications using or mentioning graph databases retrieved from PubMed and PubMed Central full-text search, focusing on the top 16 available graph databases, Publications are categorized according to their domain and application, focusing on pathway and network biology and relevant ontologies and tools. We detail different approaches and highlight the advantages of outstanding resources, such as UniProtKB, Disease Ontology, and Reactome, which provide gr

SUBMITTER: Mazein I 

PROVIDER: S-EPMC11578065 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature