Intrinsic functional connectivity in the default mode network predicts mnemonic discrimination: A connectome-based modeling approach.

ABSTRACT: The ability to distinguish existing memories from similar perceptual experiences is a core feature of episodic memory. This ability is often examined using the mnemonic similarity task in which people discriminate memories of studied objects from perceptually similar lures. Studies of the neural basis of such mnemonic discrimination have mostly focused on hippocampal function and connectivity. However, default mode network (DMN) connectivity may also support such discrimination, given that the DMN includes the hippocampus, and its connectivity supports many aspects of episodic memory. Here, we used connectome-based predictive modeling to identify associations between intrinsic DMN connectivity and mnemonic discrimination. We leveraged a wide range of abilities across healthy younger and ol

SUBMITTER: Wahlheim CN 

PROVIDER: S-EPMC11578074 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature