Pseudokinase STK40 promotes T_H1 and T_H17 cell differentiation by targeting FOXO transcription factors.

ABSTRACT: Inappropriate CD4⁺ T helper (T_H) cell differentiation leads to progression of inflammatory and autoimmune diseases, yet the regulatory mechanisms governing stability and activity of transcription factors controlling T_H cell differentiation remain elusive. Here, we describe how pseudokinase serine threonine kinase 40 (STK40) facilitates T_H1/T_H17 differentiation under pathological conditions. STK40 in T cells is dispensable for immune homeostasis in resting mice. However, mice with T cell-specific deletion of STK40 exhibit attenuated symptoms of experimental autoimmune encephalomyelitis and colitis, accompanied by diminished T_H1 and T_H17 cell differentiation. Mechanistically, STK40 facilitates K48-linked polyubiquit

SUBMITTER: Tao Y 

PROVIDER: S-EPMC11578171 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature