Ambient air pollution exposure is associated with liver fat and stiffness in Latino youth with a more pronounced effect in those with PNPLA3 genotype and more advanced liver disease.

ABSTRACT:

Background

Exposure to ambient air pollutants has emerged as a risk for metabolic-dysfunction associated steatotic liver disease (MASLD).

Objectives

We sought to examine associations between short-term (prior month) and long-term (prior year) ambient air pollution exposure with hepatic fat fraction (HFF) and liver stiffness in Latino youth with obesity. A secondary aim was to investigate effect modification by patatin-like phospholipase domain-containing protein 3 (PNPLA3) genotype and liver disease severity.

Methods

Data was analyzed from 113 Latino youth (age 11-19) with obesity in Southern California. Individual exposure to particulate matter with aerodynamic diameter ≤ 2.5μm (PM_2.5), ≤ 10μm (PM₁₀), nitrogen dioxide (NO₂), 8-hour ma

SUBMITTER: Schenker RB 

PROVIDER: S-EPMC11578286 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature