Human Serum Albumin-Coated ¹⁰B Enriched Carbon Dots as Targeted "Pilot Light" for Boron Neutron Capture Therapy.

ABSTRACT: Boron neutron capture therapy (BNCT) is a physiologically focused radiation therapy that relies on nuclear capture and fission processes. BNCT is regarded as one of the most promising treatments due to its excellent accuracy, short duration of therapy, and low side effects. The creation of novel boron medicines with high selectivity, ease of delivery, and high boron-effective load is a current research topic. Herein, boron-containing carbon dots (BCDs) and their human serum albumin (HSA) complexes (BCDs-HSA) are designed and synthesized as boron-containing drugs for BNCT. BCDs (¹⁰B: 7.1 wt%) and BCDs-HSA exhibited excitation-independent orange fluorescent emission which supported the use of fluorescence imaging for tracking ¹⁰B in vivo. The introduction of HSA enabled

SUBMITTER: Zhong T 

PROVIDER: S-EPMC11578295 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature