Cell Type-Specific Modulation of Acute Itch Processing in the Anterior Cingulate Cortex.

ABSTRACT: Despite remarkable progress in understanding the fundamental bases of itching, its cortical mechanisms remain poorly understood. Herein, the causal contributions of defined anterior cingulate cortex (ACC) neuronal populations to acute itch modulation in mice are established. Using cell type-specific manipulations, the opposing functions of ACC glutamatergic and GABAergic neurons in regulating acute itching are demonstrated. Photometry studies indicated that ACC glutamatergic neurons are activated during scratching induced by both histamine and chloroquine, whereas the activation pattern of GABAergic neurons is complicated by GABAergic subpopulations and acute itch modalities. By combining cell type- and projection-specific techniques, a thalamocortical circuit is further identified from th

SUBMITTER: Li J 

PROVIDER: S-EPMC11578322 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature