Glucocorticoid signaling mediates stress-induced migraine-like behaviors in a preclinical mouse model.

ABSTRACT:

Background

Stress is one of the most common precipitating factors in migraine and is identified as a trigger in nearly 70% of patients. Responses to stress include release of glucocorticoids as an adaptive mechanism, but this may also contribute to migraine attacks. Here, we investigated the role of glucocorticoids on stress-induced migraine-like behaviors.

Methods

We have shown previously that repeated stress in mice evokes migraine-like behavioral responses and priming to a nitric oxide donor. Metyrapone, mifepristone, and corticosterone (CORT) were used to investigate whether CORT contributes to the stress-induced effects. Facial mechanical hypersensitivity was evaluated by von Frey testing and grimace scoring assessed the presence of non-evoked pain. We also measured ser

SUBMITTER: Hu YY 

PROVIDER: S-EPMC11578425 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature