The links between neuroinflammation, brain structure and depressive disorder: A cross-sectional study protocol.

ABSTRACT:

Introduction

It is known that symptoms of major depressive disorder (MDD) are associated with neurodegeneration, that lipopolysaccharide (LPS) can induce symptoms of MDD, and that blood LPS levels are elevated in neurodegeneration. However, it is not known whether blood LPS and cytokine levels correlate with MDD, cognition and brain structure, and this is tested in this study.

Methods and analysis

This cross-sectional study includes individuals with MDD (n = 100) and a control group of individuals with no one-year history of a mental disorder (n = 50). A comprehensive evaluation is performed, including the collection of basic sociodemographic information, data on smoking status, body mass index, course of MDD, past treatment, comorbid diseases, and current use of medications

SUBMITTER: Milasauskiene E 

PROVIDER: S-EPMC11578540 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature