Genetic stability of Mycobacterium smegmatis under the stress of first-line antitubercular agents.

ABSTRACT: The sustained success of Mycobacterium tuberculosis as a pathogen arises from its ability to persist within macrophages for extended periods and its limited responsiveness to antibiotics. Furthermore, the high incidence of resistance to the few available antituberculosis drugs is a significant concern, especially since the driving forces of the emergence of drug resistance are not clear. Drug-resistant strains of Mycobacterium tuberculosis can emerge through de novo mutations, however, mycobacterial mutation rates are low. To unravel the effects of antibiotic pressure on genome stability, we determined the genetic variability, phenotypic tolerance, DNA repair system activation, and dNTP pool upon treatment with current antibiotics using Mycobacterium smegmatis. Whole-g

SUBMITTER: Molnar D 

PROVIDER: S-EPMC11578590 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature