Water Extracts of <i>Moringa oleifera</i> Leaves Alter Oxidative Stress-Induced Neurotoxicity in Human Neuroblastoma SH-SY5Y Cells.

ABSTRACT: Moringa oleifera (MO) has been an important plant for food and traditional medicine in Asian countries, including Indonesia. The leaves of these plants are reported to be rich in antioxidants, vitamins, and micronutrients and have been proven to have nootropic properties. Therefore, we investigated whether MO could provide protective effects on SH-SY5Y neuroblastoma cells exposed to H₂O₂. In this study, we observed cotreating water-extracted MO leaves on the inhibition of reactive oxygen species (ROS). We found that this treatment enhanced the activities of glutathione peroxidase, catalase, and superoxide dismutase. In addition, it suppressed the mRNA expression levels of apoptotic gene-related genes, specifically Bcl-2 associated protein X (BAX) and caspase 3.

SUBMITTER: Barinda AJ 

PROVIDER: S-EPMC11578659 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature