Computational proteomics analysis of Taphrina deformans for the identification of antifungal drug targets and validation with commercial fungicides.

ABSTRACT: Taphrina deformans is a plant-pathogenic fungus and a responsible agent for causing peach leaf curl disease. Taphrina deformans affects peach fruit production and contributes to global economic losses. Commercial fungicides may provide temporary relief; however, their overuse resulted in adverse environmental consequences as well as led to drug-resistant strains of T. deformans. Therefore, the discovery of novel drug targets for the future synthesis of antifungal drugs against Taphrina deformans is needed. Here we studied Taphrina deformans by computational proteomics approaches. The whole genome and proteome of T. deformans were subjected to subtractive proteomics, high-throughput virtual screening, and molecular dynamic simulations. We emp

SUBMITTER: Ahmad W 

PROVIDER: S-EPMC11578757 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature