Measurement of circulating viral antigens post-SARS-CoV-2 infection in a multicohort study.

ABSTRACT:

Objectives

To determine the proportion of individuals with detectable antigen in plasma or serum after SARS-CoV-2 infection and the association of antigen detection with postacute sequelae of COVID-19 (PASC) symptoms.

Methods

Plasma and serum samples were collected from adults participating in four independent studies at different time points, ranging from several days up to 14 months post-SARS-CoV-2 infection. The primary outcome measure was to quantify SARS-CoV-2 antigens, including the S1 subunit of spike, full-length spike, and nucleocapsid, in participant samples. The presence of 34 commonly reported PASC symptoms during the postacute period was determined from participant surveys or chart reviews of electronic health records.

Results

Of the 1569 samples analysed

SUBMITTER: Swank Z 

PROVIDER: S-EPMC11578795 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature