The role of SIRT1-FXR signaling pathway in valproic acid induced liver injury: a quantitative targeted metabolomic evaluation in epileptic children.

ABSTRACT:

Aim

This study aimed to gain deeper insights into the hepatotoxicity mechanisms of valproic acid (VPA), as well as to identify potential risk markers for VPA-induced hepatotoxicity.

Methods

Twenty-two children with epilepsy treated with VPA monotherapy were divided into a normal liver function (NLF) group, a mild abnormal liver function (ANLF1) group, and a serious abnormal liver function (ANLF2) group based on their liver function indicator levels. The full quantitative targeted metabolomics technique was used to systematically investigate how the differential endogenous metabolic components change with the development of liver injury.

Results

A total of 195 metabolic components were quantitatively analyzed. Nineteen identified metabolites, including five organic aci

SUBMITTER: Zhao M 

PROVIDER: S-EPMC11578826 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature