The physiological determinants of symptom burden in cirrhosis with ascites.

ABSTRACT:

Background & aims

Paracentesis is commonly used to manage patient discomfort due to ascites. The relationship between ascites pressure, ascites volume, and patient discomfort has not been elucidated.

Methods

We prospectively enrolled adult patients with non-malignant ascites undergoing outpatient therapeutic paracenteses from 2021 to 2024 at a tertiary care hospital. Patients completed a validated symptom questionnaire (ASI-7, maximum score 35) before, immediately after, and 1 week after paracentesis. An open-ended manometer was used to measure ascites pressure at the beginning and end of paracentesis. Mixed effect linear regression was performed to evaluate the relationships between patient characteristics, pressure, volume, and symptoms.

Results

One hundred and fift

SUBMITTER: Mazumder NR 

PROVIDER: S-EPMC11578835 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature