Defining mucosal healing in randomized controlled trials of inflammatory bowel disease: A systematic review and future perspective.

ABSTRACT:

Background

Mucosal healing (MH) is an established treatment goal in inflammatory bowel disease (IBD). However, various definitions of MH exist. We aimed to identify how MH is defined in randomized controlled trials (RCTs) in ulcerative colitis (UC) and Crohn's disease (CD).

Methods

We searched MEDLINE, EMBASE, and the Cochrane library from inception to December 2023 for phase 2 and 3 RCTs of advanced therapies in IBD.

Results

One hundred forty-four studies were included, 72 in UC and 72 in CD, published between 1997 and 2023. In UC, 64% (46/72) RCTs reported MH as an endpoint. 12 definitions of MH were found, from endoscopic assessment alone (35/46; 76%) to the more recent combination of histology and endoscopy (10/46; 22%). 96% (44/46) of studies used the Mayo Endosc

SUBMITTER: Parigi TL 

PROVIDER: S-EPMC11578850 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature