A bacterial immunity protein directly senses two disparate phage proteins.

ABSTRACT: Eukaryotic innate immune systems use pattern recognition receptors to sense infection by detecting pathogen-associated molecular patterns, which then triggers an immune response. Bacteria have similarly evolved immunity proteins that sense certain components of their viral predators, known as bacteriophages^1-6. Although different immunity proteins can recognize different phage-encoded triggers, individual bacterial immunity proteins have been found to sense only a single trigger during infection, suggesting a one-to-one relationship between bacterial pattern recognition receptors and their ligands^7-11. Here we demonstrate that the antiphage defence protein CapRel^SJ46 in Escherichia coli can directly bind and sense two completely unrelated and structurally d

SUBMITTER: Zhang T 

PROVIDER: S-EPMC11578894 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature