Childhood neglect is associated with alterations in neural prediction error signaling and the response to novelty.

ABSTRACT:

Background

One in eight children experience early life stress (ELS), which increases risk for psychopathology. ELS, particularly neglect, has been associated with reduced responsivity to reward. However, little work has investigated the computational specifics of this disrupted reward response - particularly with respect to the neural response to Reward Prediction Errors (RPE) - a critical signal for successful instrumental learning - and the extent to which they are augmented to novel stimuli. The goal of the current study was to investigate the associations of abuse and neglect, and neural representation of RPE to novel and non-novel stimuli.

Methods

One hundred and seventy-eight participants (aged 10-18, M = 14.9, s.d. = 2.38) engaged in the Novelty task while unde

SUBMITTER: Aloi J 

PROVIDER: S-EPMC11578899 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature