Personality changes during adolescence predict young adult psychosis proneness and mediate gene-environment interplays of schizophrenia risk.

ABSTRACT:

Background

Psychotic symptoms in adolescence are associated with social adversity and genetic risk for schizophrenia. This gene-environment interplay may be mediated by personality, which also develops during adolescence. We hypothesized that (i) personality development predicts later Psychosis Proneness Signs (PPS), and (ii) personality traits mediate the association between genetic risk for schizophrenia, social adversities, and psychosis.

Methods

A total of 784 individuals were selected within the IMAGEN cohort (Discovery Sample-DS: 526; Validation Sample-VS: 258); personality was assessed at baseline (13-15 years), follow-up-1 (FU1, 16-17 years), and FU2 (18-20 years). Latent growth curve models served to compute coefficients of individual change across 14 personality va

SUBMITTER: Antonucci LA 

PROVIDER: S-EPMC11578906 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature