Polygenic liabilities and treatment trajectories in early-onset depression: a Danish register-based study.

ABSTRACT:

Background

The clinical course of major depressive disorder (MDD) is heterogeneous, and early-onset MDD often has a more severe and complex clinical course. Our goal was to determine whether polygenic scores (PGSs) for psychiatric disorders are associated with treatment trajectories in early-onset MDD treated in secondary care.

Methods

Data were drawn from the iPSYCH2015 sample, which includes all individuals born in Denmark between 1981 and 2008 who were treated in secondary care for depression between 1995 and 2015. We selected unrelated individuals of European ancestry with an MDD diagnosis between ages 10-25 (N = 10577). Seven-year trajectories of hospital contacts for depression were modeled using Latent Class Growth Analysis. Associations between PGS for MDD, bi

SUBMITTER: Mundy J 

PROVIDER: S-EPMC11578915 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature