Co-stimulation of muscarinic M1 and M4 acetylcholine receptors prevents later cocaine reinforcement in male and female mice, but not place-conditioning.

ABSTRACT: Acute stimulation of M₁ or M₄ muscarinic cholinergic receptors reduces cocaine abuse-related effects in mice and rats. The combined activation of these receptor subtypes produces synergistic effects on some behavioural endpoints in mice. M₁ and M₁ + M₄ receptor stimulation in a cocaine vs. food choice assay in rats and microdialysis in rats showed delayed and lasting "anticocaine effects". Here, we tested whether these putative lasting neuroplastic changes are sufficient to occlude the reinforcing effects of cocaine at the behavioural level in mice. Mice were pre-treated with the M₁ receptor partial agonist VU0364572, M₄ receptor positive allosteric modulator VU0152100, or VU0364572 + VU0152100 two weeks prior to

SUBMITTER: Balakrishnan AS 

PROVIDER: S-EPMC11578924 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature