MICA and NKG2D gene polymorphisms influence graft survival, and response to therapy in kidney transplantation.

ABSTRACT:

Background

Antibody-mediated rejection is a significant cause of kidney transplant failure. Recent studies have shown that the MHC class I MICA gene influences the transplantation outcome. However, the role of the primary MICA receptor, NKG2D, has yet to be explored.

Aim

We aimed to investigate the correlation between recipient/donor MICA allele matching and NKG2D genotype with the risk of antibody-mediated rejection and their potential clinical effects and implications for organ maintenance therapy.

Methods

Of the 524 patients who underwent transplantation, 387 were eligible for the study. Complete MICA allele and two functional polymorphisms of NKG2D (rs1049174C>G and rs2255336G>A) were analyzed in 148 transpla

SUBMITTER: Littera R 

PROVIDER: S-EPMC11578996 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature