Causal association between plasma metabolites and diverse autoimmune diseases: a two-sample bidirectional mendelian randomization study.

ABSTRACT:

Background

Autoimmune diseases (ADs) are a category of conditions characterized by misrecognition of autologous tissues and organs by the immune system, leading to severe impairment of patients' health and quality of life. Increasing evidence suggests a connection between fluctuations in plasma metabolites and ADs. However, the existence of a causal relationship behind these associations remains uncertain.

Methods

Applying the two-sample mendelian randomization (MR) method, the reciprocal causality between plasma metabolites and ADs was analyzed. We took the intersection of two metabolite genome-wide association study (GWAS) datasets for GWAS-meta and obtained 1,009 metabolites' GWAS data using METAL software. We accessed GWAS summary statistics for 5 common ADs, inflammator

SUBMITTER: Yuan X 

PROVIDER: S-EPMC11578997 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature