Systematic regulation of immune checkpoint molecules by redox regulators CNC-bZIP transcription factors.

ABSTRACT:

Background

Although oxidative stress is strongly connected to the initiation and progression of cancer, the underlying molecular pathways remain unknown. The redox regulator CNC-bZIPs are important transcription factor groups that mediate the interplay of environmental cues and intercellular homeostasis. Immune checkpoint molecules (ICMs) are key molecules that mediate the communication between immune cells and tumor cells. This research sought to explore the transcriptional regulatory effects of CNC-bZIPs on ICMs.

Methods

The potential role of CNC-bZIPs in tumors and the correlation between CNC-bZIPs and ICMs were analyzed by the gene expression characteristics, survival analysis, and correlation analysis in TCGA data. And the transcriptional regulatory effects of CNC-bZIPs

SUBMITTER: Ning H 

PROVIDER: S-EPMC11579261 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature