Mycobacterium tuberculosis infection and tuberculosis disease in the first decade of life: a South African birth cohort study.

ABSTRACT:

Background

Paediatric tuberculosis leads to more than 200 000 deaths annually. We aimed to investigate the incidence of Mycobacterium tuberculosis infection and tuberculosis disease in the first decade of life in the Drakenstein Child Health Study (DCHS), a South African cohort in a community with high tuberculosis and HIV incidence.

Methods

In this prospective birth cohort study, we enrolled pregnant women aged 18 years or older who were between 20 and 28 weeks' of gestation in a peri-urban setting outside of Cape Town, South Africa. We followed up their children for tuberculosis until age 10 years. To measure M tuberculosis infection tuberculin skin tests were administered to children at age 6 months, 12 months, and then annually in children with a negative test, and at th

SUBMITTER: da Costa FBP 

PROVIDER: S-EPMC11579303 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature