Cell hiding in colorectal cancer: correlation with response to chemotherapy in vitro and in vivo.

ABSTRACT: Resistance to chemotherapy remains the main challenge for cancer treatment. One of the mechanisms of tumor escape from cytotoxic agents could be the formation of cell-in-cell (CIC) structures, in which the outer cell protects the inner cell from unfavorable environment. Such structures have been found in many tumor types, however, their link to chemosensitivity is elusive. Here, we tested whether the CIC structures can promote resistance of colorectal cancer cells to chemotherapy. To identify CIC structures in cell cultures and in tumor xenografts, both transmission electron microscopy and confocal fluorescence microscopy of live and fixed cells as well as tissue slices and histopathology were used. Cytogenetic analysis was performed to detect chromosome instability associated with the dru

SUBMITTER: Druzhkova I 

PROVIDER: S-EPMC11579335 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature