Genetic variants associated with longevity in long-living Indians.

ABSTRACT: Genetic factors play a significant role in determining an individual's longevity. The present study was aimed at identifying genetic variants associated with longevity in Indian population. Long living individuals (LLIs), aged 85+, were compared with younger controls, aged 18-49 years, using data from GenomegaDB, a genetic database of Indians living in India. An in-house developed custom chip, having variants associated with various cancers, cardiovascular, neurological, gastro-intestinal, metabolic and auto-immune disorders, was used to generate genotype data. Logistic regression analysis with sex and top three genetic principal components as covariates resulted in 9 variants to be significantly associated with longevity at a p-value threshold of 5 × 10^-4. Alleles associated wi

SUBMITTER: Pemmasani SK 

PROVIDER: S-EPMC11579347 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature