Embryo movement is required for limb tendon maturation.

ABSTRACT:

Introduction

Following early cell specification and tenocyte differentiation at the sites of future tendons, very little is known about how tendon maturation into robust load-bearing tissue is regulated. Between embryonic day (E)16 and E18 in the chick, there is a rapid change in mechanical properties which is dependent on normal embryo movement. However, the tissue, cellular and molecular changes that contribute to this transition are not well defined.

Methods

Here we profiled aspects of late tendon development (collagen fibre alignment, cell organisation and Yap pathway activity), describing changes that coincide with tissue maturation. We compared effects of rigid (constant static loading) and flaccid (no loading) immobilisation to gain insight into developmental steps in

SUBMITTER: Rolfe RA 

PROVIDER: S-EPMC11579356 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature