Individuals with psychosis receive less electric field strength during transcranial direct current stimulation compared to healthy controls.

ABSTRACT: Recent research has examined the effectiveness of transcranial direct current stimulation (tDCS) as an adjunctive treatment for antipsychotics, finding mixed results on cognitive, positive, and negative symptoms. We tested if individuals with psychosis have reduced electric field strength compared to healthy controls and assessed the potential causal factors. We hypothesized that either cortical thinning due to the disorder or increased scalp thickness due to secondary effects of the disorder were causal factors. Using the Psychosis Human Connectome Project dataset, we simulated electric field models for 136 individuals with psychosis, 73 first-degree relatives, and 43 healthy controls. We compared group differences of electric field strength at bilateral dorsolateral prefrontal cortex (dl

SUBMITTER: Kazinka R 

PROVIDER: S-EPMC11579372 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature