The impact of ulinastatin on lymphocyte apoptosis and autophagy in sepsis patients.

ABSTRACT: This study aimed to assess the influence of ulinastatin (UTI) on lymphocyte apoptosis and autophagy in sepsis patients, as well as its effect on inflammatory factors and vital organ function, with the goal of providing insights for improved clinical management of sepsis. A total of 40 sepsis patients were randomly assigned to the UTI group or the control group. The UTI group received standard treatment plus intravenous UTI, while the control group received standard treatment alone. Peripheral blood samples were collected at multiple time points for analysis of lymphocyte apoptosis, autophagy, inflammatory markers, and organ function. Various experimental techniques including Hoechst staining, transmission electron microscopy, and Western blot analysis were utilized to assess lymphocyte apo

SUBMITTER: Zhang D 

PROVIDER: S-EPMC11579385 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature