Sex difference in the risk of coronary artery calcification progression related to hyperuricemia among asymptomatic 12,316 Korean adults.

ABSTRACT: Data on hyperuricemia-related changes in coronary atherosclerosis are limited, especially in sex difference. This study evaluated the association between hyperuricemia and coronary artery calcification (CAC) progression in asymptomatic Korean men and women. We analysed the data of 12,316 asymptomatic adults (51.7 ± 8.5 years; 84.2% men) with a mean follow-up of 3.3 years. Participants were divided into two groups: those with and without hyperuricemia (serum uric acid levels > 7.0 mg/dL for men and > 6.0 mg/dL for women). CAC progression was defined as a difference of ≥ 2.5 between the square roots of the baseline and follow-up coronary artery calcium score (CACS) (Δ√transformed CACS). The incidence of CAC progression was higher in men with hyperuricemia than in those without the condition

SUBMITTER: Won KB 

PROVIDER: S-EPMC11579511 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature