Radiomultiomics: quantitative CT clusters of severe asthma associated with multiomics.

ABSTRACT:

Background

Lung quantitative computed tomography (qCT) severe asthma clusters have been reported, but their replication and underlying disease mechanisms are unknown. We identified and replicated qCT clusters of severe asthma in two independent asthma cohorts and determined their association with molecular pathways, using radiomultiomics, integrating qCT, multiomics and machine learning/artificial intelligence.

Methods

We used consensus clustering on qCT measurements of airway and lung CT scans, performed in 105 severe asthmatic adults from the U-BIOPRED cohort. The same qCT measurements were used to replicate qCT clusters in a subsample of the ATLANTIS asthma cohort (n=97). We performed integrated enrichment analysis using blood, sputum, bronchial biopsies, bronchial brushi

SUBMITTER: Zounemat Kermani N 

PROVIDER: S-EPMC11579543 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature