Defining causes of death-censored kidney allograft failure: A 5-year multicentre ANZDATA and clinical cross-sectional study.

ABSTRACT:

Aim

Determining specific causes of allograft failure allows a focus on understanding and treating these conditions. Previous studies highlight chronic antibody-mediated rejection as a leading cause of late allograft failure. We sought to define causes of allograft failure in a large cohort of kidney transplant recipients across multiple centres in Australia and New Zealand, including cases previously attributed to chronic allograft nephropathy (CAN).

Methods

All death-censored allograft failures at 9 participating centres between 1 January 2014 to 31 December 2018 were included. Available clinical and biopsy data were reviewed and the "most likely" cause assigned.

Results

There were 642 death-censored allograft failures in the study period. Of these, 495 (77.1%) had a

SUBMITTER: Mulley WR 

PROVIDER: S-EPMC11579561 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature