Leveraging the Photofunctions of Transition Metal Complexes for the Design of Innovative Phototherapeutics.

ABSTRACT: Despite the advent of various medical interventions for cancer treatment, the disease continues to pose a formidable global health challenge, necessitating the development of new therapeutic approaches for more effective treatment outcomes. Photodynamic therapy (PDT), which utilizes light to activate a photosensitizer to produce cytotoxic reactive oxygen species (ROS) for eradicating cancer cells, has emerged as a promising approach for cancer treatment due to its high spatiotemporal precision and minimal invasiveness. However, the widespread clinical use of PDT faces several challenges, including the inefficient production of ROS in the hypoxic tumor microenvironment, the limited penetration depth of light in biological tissues, and the inadequate accumulation of photosensitizers at the t

SUBMITTER: Lee LC 

PROVIDER: S-EPMC11579581 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature