Integrated elemental analysis supports targeting copper perturbations as a therapeutic strategy in multiple sclerosis.

ABSTRACT: Multiple sclerosis (MS) is a debilitating affliction of the central nervous system (CNS) that involves demyelination of neuronal axons and neurodegeneration resulting in disability that becomes more pronounced in progressive forms of the disease. The involvement of neurodegeneration in MS underscores the need for effective neuroprotective approaches necessitating identification of new therapeutic targets. Herein, we applied an integrated elemental analysis workflow to human MS-affected spinal cord tissue utilising multiple inductively coupled plasma-mass spectrometry methodologies. These analyses revealed shifts in atomic copper as a notable aspect of disease. Complementary gene expression and biochemical analyses demonstrated that changes in copper levels coincided with altered expression

SUBMITTER: Hilton JBW 

PROVIDER: S-EPMC11579877 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature