Bioengineered Human Arteries for the Repair of Vascular Injuries.

ABSTRACT:

Importance

Vascular injuries require urgent repair to minimize loss of limb and life. Standard revascularization relies on autologous vein or synthetic grafts, but alternative options are needed when adequate vein is not feasible and when clinical conditions preclude safe use of synthetic materials.

Objective

To evaluate the performance of the acellular tissue engineered vessel (ATEV) in the repair of arterial injuries.

Design, setting, and participants

Two open-label, single-arm, nonrandomized clinical trials, including 1 prospective civilian study (CLN-PRO-V005 [V005]) and 1 retrospective observational study in a war zone (CLN-PRO-V017 [V017]), were conducted from September 2018 to January 2024 (follow-up ongoing) at 19 level 1 trauma centers in the US and Israel an

SUBMITTER: Moore EE 

PROVIDER: S-EPMC11579887 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature