Skin Inflammation, Systemic Inflammation, and Cardiovascular Disease in Psoriasis.

ABSTRACT:

Importance

Psoriasis is associated with increased cardiovascular risk, but the underlying pathogenic mechanisms remain unclear. Elucidating these mechanisms can help develop treatment strategies and enhance understanding of the link between peripheral inflammation, such as psoriatic skin lesions, and cardiovascular disease (CVD).

Objective

To explore whether systemic inflammation is a mediator of the association between psoriasis skin disease severity and CVD.

Design, setting, and participants

This cohort study used data from cross-sectional study (Psoriasis Atherosclerosis and Cardiometabolic Disease Initiative [PACI]), which enrolled patients from January 2013 to February 2022, and an inception cohort study (Stockholm Psoriasis Cohort [SPC]), which enrolled patients

SUBMITTER: Svedbom A 

PROVIDER: S-EPMC11579891 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature