Dose, exposure, and treatment regimen of intravenous immunoglobulin G in multifocal motor neuropathy.

ABSTRACT:

Introduction

Intravenous immunoglobulin (IVIG) is the only approved treatment for multifocal motor neuropathy (MMN), a rare, chronic, immune-mediated demyelinating neuropathy. There is a significant gap in understanding of the role of serum immunoglobulin G (IgG) levels in the efficacy of IVIG in affected patients. We aimed to characterize the interplay between dose and exposure of IVIG and the effects of patient factors on individual variabilities.

Methods

Serum IgG trough concentration data from a phase 3, randomized, double-blind, placebo-controlled, crossover trial of IVIG 10% in 44 patients with MMN (NCT00666263) were analyzed using fit-for-purpose population PK modeling. Patient factors were tested as covariates, and IgG PK profiles following various dosing regimens we

SUBMITTER: Li Z 

PROVIDER: S-EPMC11580011 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature