Improved reproducibility of γ-aminobutyric acid measurement from short-echo-time proton MR spectroscopy by linewidth-matched basis sets in LCModel.

ABSTRACT: γ-Aminobutyric acid (GABA), as the primary inhibitory neurotransmitter, is extremely important for maintaining healthy brain function, and deviations from GABA homeostasis are related to various brain diseases. Short-echo-time (short-TE) proton MR spectroscopy (¹ H-MRS) has been employed to measure GABA concentration from various human brain regions at high magnetic fields. The aim of this study was to investigate the effect of spectral linewidth on GABA quantification and explore the application of an optimized basis-set preparation approach using a spectral-linewidth-matched (LM) basis set in LCModel to improve the reproducibility of GABA quantification from short-TE ¹ H-MRS. In contrast to the fixed-linewidth basis-set approach, the LM basis-set preparation approac

SUBMITTER: Xiao Y 

PROVIDER: S-EPMC11580110 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature