Comparing human and macaque placental transcriptomes to disentangle preterm birth pathology from gestational age effects.

ABSTRACT:

Introduction

A major issue in the transcriptomic study of spontaneous preterm birth (sPTB) in humans is the inability to collect healthy control tissue at the same gestational age (GA) to compare with pathologic preterm tissue. Thus, gene expression differences identified after the standard comparison of sPTB and term tissues necessarily reflect differences in both sPTB pathology and GA. One potential solution is to use GA-matched controls from a closely related species to tease apart genes that are dysregulated during sPTB from genes that are expressed differently as a result of GA effects.

Methods

To disentangle genes whose expression levels are associated with sPTB pathology from those linked to GA, we compared RNA sequencing data from human preterm placentas, human term

SUBMITTER: Eidem HR 

PROVIDER: S-EPMC11580153 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature