Ficolin-1 ameliorates pulmonary fibrosis via directly binding to TGF-β1.

ABSTRACT:

Background

Ficolins were originally identified as proteins that bind to transforming growth factor-β1 (TGF-β1). They are capable of activating the complement system through lectin pathway for immune system protection. Ficolin-2 and 3 have been identified in patients with interstitial lung diseases (ILD) and their function in these diseases is currently being explored. In contrast, the functional role of ficolin-1 in pulmonary fibrosis is still elusive and remains to be elucidated.

Methods

The expression of ficolin-1 in the plasma of idiopathic pulmonary fibrosis (IPF) and connective tissue disease (CTD)-ILD patients was first determined. As the orthologue of human ficolin-1, ficolin-B knockout and ficolin-B overexpression were used to establish bleomycin (BLM)-induced pulmon

SUBMITTER: Gao P 

PROVIDER: S-EPMC11580187 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature