Cyclosporine successfully treats steroid-resistant checkpoint inhibitor-related pneumonitis: a case report.

ABSTRACT:

Background

Immune checkpoint inhibitor-related pneumonitis (CIP) stands out as a particularly severe adverse event caused by immune checkpoint inhibitors, with a substantial real-world incidence ranging from 13 to 19%. While systemic corticosteroids represent the standard treatment for CIP, therapeutic options become limited in cases where patients do not respond to corticosteroid therapy. Such patients are classified as having steroid-resistant CIP, often associated with a poor prognosis. This case study provides insight into the symptoms, diagnostic process, and treatment approach for steroid-resistant CIP. Notably, successful management is demonstrated through the utilization of cyclosporine, highlighting its potential mechanisms of action in effectively treating steroid-resista

SUBMITTER: Deng J 

PROVIDER: S-EPMC11580203 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature