Association of asthma and bronchiectasis: Mendelian randomization analyses and observational study.

ABSTRACT:

Background

Previous studies have demonstrated that asthma is closely associated with bronchiectasis, however, the causal relationship between asthma and bronchiectasis has not been investigated in depth. Therefore, this study aims to explore the causal relationship and to identify potential factors that mediate between these two diseases.

Method

All the necessary summarized information were obtained from publicly available genome-wide association study (GWAS). Two-sample Mendelian randomization (two-sample MR) was employed to explore the causal relationship between asthma and bronchiectasis, with an additional dataset used for validation. Heterogeneity and pleiotropy analyses were utilized to verify the robustness of the results. Subsequently, mediation MR analyses were perf

SUBMITTER: Fan R 

PROVIDER: S-EPMC11580211 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature