Risk of dementia associated with anticholinergic drugs for overactive bladder in adults aged ≥55 years: nested case-control study.

ABSTRACT:

Abstract

Objective

To investigate whether different anticholinergic drug treatments for overactive bladder have differential risks for incident dementia, in a large representative population of older adults in England.

Design

Nested case-control study.

Setting

General practices in England providing data to the Clinical Practice Research Datalink (CPRD) GOLD database, with linked patient admission records from secondary care (Hospital Episode Statistics), 1 January 2006 and 16 February 2022.

Participants

170 742 patients aged ≥55 years, with a first reported diagnosis of dementia during the study period, matched by age, sex, and general practice with 804 385 individuals without dementia (controls).

Interventions

Cumulative drug use (defined using

SUBMITTER: Iyen B 

PROVIDER: S-EPMC11580265 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature