Estimating the herd effects of anti-microbial-based decontamination (ABD) interventions on intensive care unit (ICU) acquired bloodstream infections: a deductive meta-analysis.

ABSTRACT:

Objective

To estimate the herd effects of anti-microbial-based decontamination (ABD) interventions on bloodstream infections (BSIs) among groups of intensive care unit (ICU) patients in relation to group mean length of stay (LOS). To deduce which of three competing hypotheses of ABD effect mediation best accounts for the observed effects.

Design

Arms-based meta-regression of ICU-acquired BSI incidence against group mean LOS for control and interventions arms of ABD and non-ABD controlled trials each versus that in arms of observational studies.

Exposures

Within controlled trials of ABD, intervention, concurrent control (CC) and non-concurrent (NCC) groups are directly, indirectly and non-exposed, respectively.

Main outcomes and measures

BSI incidence, both over

SUBMITTER: Hurley J 

PROVIDER: S-EPMC11580273 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature